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COBRA1
an essential subunit of the multisubunit transcription elongation factor NELF (negative elongation factor), a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes. Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules. Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes. Interacts with the first BRCT repeat of BRCA1. Belongs to the NELF-B family. Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 9q34.3 |
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Cellular Component:
cytoplasm; NELF complex; nucleoplasm; nucleus
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Molecular Function:
protein binding; RNA binding
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Biological Process:
cell population proliferation; negative regulation of stem cell differentiation; negative regulation of transcription elongation by RNA polymerase II; stem cell differentiation
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Reference #:
Q8WX92
(UniProtKB)
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Alt. Names/Synonyms: COBRA1; Cofactor of BRCA1; DKFZp586B0519; KIAA1182; Negative elongation factor B; negative elongation factor complex member B; negative elongation factor protein B; NELF-B; NELFB
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Gene Symbols: NELFB
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Molecular weight:
65,697 Da
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Basal Isoelectric point:
5.77
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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