COBRA1 an essential subunit of the multisubunit transcription elongation factor NELF (negative elongation factor), a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes. Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules. Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes. Interacts with the first BRCT repeat of BRCA1. Belongs to the NELF-B family. Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component:  cytoplasm; NELF complex; nucleoplasm
Molecular Function:  protein binding; RNA binding
Biological Process:  cell proliferation; negative regulation of stem cell differentiation; negative regulation of transcription elongation from RNA polymerase II promoter; positive regulation of viral transcription; stem cell differentiation; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter
Reference #:  Q8WX92 (UniProtKB)
Alt. Names/Synonyms: COBRA1; Cofactor of BRCA1; DKFZp586B0519; KIAA1182; Negative elongation factor B; negative elongation factor complex member B; negative elongation factor protein B; NELF-B; NELFB
Gene Symbols: NELFB
Molecular weight: 65,697 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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COBRA1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA