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PPAT iso2
Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. In the central section; belongs to the eukaryotic CoaD family. Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.7.1.24; EC 2.7.7.3; Kinase, other; Transferase |
| Chromosomal Location of human Ortholog: 17q21.2 |
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Cellular Component:
mitochondrial matrix; mitochondrial outer membrane
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Molecular Function:
ATP binding; dephospho-CoA kinase activity; pantetheine-phosphate adenylyltransferase activity; protein binding
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Biological Process:
coenzyme A biosynthetic process; phosphorylation
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Reference #:
Q13057-2
(UniProtKB)
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Alt. Names/Synonyms: Bifunctional coenzyme A synthase; bifunctional phosphopantetheine adenylyl transferase/dephospho CoA kinase; CoA synthase; COASY; coASy beta; Coenzyme A synthase; Dephospho-CoA kinase; Dephospho-CoA pyrophosphorylase; Dephosphocoenzyme A kinase; DPCK; DPCOAK; NBIA6; NBP; nucleotide binding protein; Pantetheine-phosphate adenylyltransferase; PCH12; Phosphopantetheine adenylyltransferase; phosphopantetheine adenylyltransferase / dephosphocoenzyme A kinase; POV-2; PPAT; PPAT iso2; UKR1
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Gene Symbols: COASY
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Molecular weight:
65,339 Da
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Basal Isoelectric point:
7.29
Predict pI for various phosphorylation states
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