CDT1 Required for both DNA replication and mitosis. DNA replication licensing factor, required for pre-replication complex assembly. Cooperates with CDC6 and the origin recognition complex (ORC) during G1 phase of the cell cycle to promote the loading of the mini-chromosome maintenance (MCM) complex onto DNA to generate pre-replication complexes (pre-RC)(PubMed:14672932). Required also for mitosis by promoting stable kinetochore-microtubule attachments. Potential oncogene. Belongs to the Cdt1 family. Note: This description may include information from UniProtKB.
Protein type: DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component:  condensed chromosome kinetochore; cytosol; kinetochore; nuclear body; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; protein binding
Biological Process:  attachment of mitotic spindle microtubules to kinetochore; cell division; chromosome segregation; deactivation of mitotic spindle assembly checkpoint; DNA replication checkpoint; DNA replication preinitiation complex assembly; G1/S transition of mitotic cell cycle; kinetochore organization; mitotic cell cycle; negative regulation of protein localization to kinetochore; positive regulation of chromatin binding; positive regulation of DNA replication; positive regulation of DNA-dependent DNA replication; positive regulation of mediator complex assembly; positive regulation of protein complex assembly; positive regulation of protein localization to kinetochore; regulation of chromosome organization; regulation of DNA replication origin binding; regulation of DNA-dependent DNA replication initiation; regulation of nuclear cell cycle DNA replication; regulation of transcription involved in G1/S transition of mitotic cell cycle; response to sorbitol
Disease: Meier-gorlin Syndrome 4
Reference #:  Q9H211 (UniProtKB)
Alt. Names/Synonyms: CDT1; chromatin licensing and DNA replication factor 1; DNA replication factor Cdt1; Double parked homolog; Double parked, Drosophila, homolog of; DUP; RIS2
Gene Symbols: CDT1
Molecular weight: 60,390 Da
Basal Isoelectric point: 9.82  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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