CTNNA1 Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. Belongs to the vinculin/alpha-catenin family. Expressed ubiquitously in normal tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 5q31.2
Cellular Component:  acrosomal vesicle; actin cytoskeleton; catenin complex; cell junction; cell-cell junction; cytosol; flotillin complex; Golgi apparatus; intercalated disc; intracellular membrane-bounded organelle; lamellipodium; plasma membrane; zonula adherens
Molecular Function:  actin filament binding; beta-catenin binding; cadherin binding; gamma-catenin binding; identical protein binding; protein binding; protein heterodimerization activity; structural molecule activity; vinculin binding
Biological Process:  actin filament organization; adherens junction organization; aging; apical junction assembly; axon regeneration; cell adhesion; cellular protein localization; cellular response to indole-3-methanol; epithelial cell-cell adhesion; establishment or maintenance of cell polarity; gap junction assembly; male gonad development; negative regulation of cell motility; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of integrin-mediated signaling pathway; negative regulation of neuroblast proliferation; odontogenesis of dentin-containing tooth; ovarian follicle development; positive regulation of extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of muscle cell differentiation; positive regulation of smoothened signaling pathway; protein heterooligomerization; response to estrogen
Disease: Macular Dystrophy, Patterned, 2
Reference #:  P35221 (UniProtKB)
Alt. Names/Synonyms: Alpha E-catenin; alpha-catenin; alpha-E-catenin; alphaE-catenin; Cadherin-associated protein; cadherin-associated protein,102kDa; CAP102; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha 1; Catenin alpha-1; CTNA1; CTNNA1; epididymis secretory sperm binding protein; FLJ36832; FLJ52416; MDPT2; Renal carcinoma antigen NY-REN-13
Gene Symbols: CTNNA1
Molecular weight: 100,071 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene