BCLAF1 Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Belongs to the BCLAF1/THRAP3 family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6q23.3
Cellular Component:  cytoplasm; nuclear speck; nucleoplasm; nucleus
Molecular Function:  DNA binding; protein binding
Biological Process:  apoptotic process; cellular response to leukemia inhibitory factor; negative regulation of transcription, DNA-templated; positive regulation of apoptotic process; positive regulation of DNA-templated transcription, initiation; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of response to DNA damage stimulus; regulation of DNA-templated transcription in response to stress
Reference #:  Q9NYF8 (UniProtKB)
Alt. Names/Synonyms: Bcl-2-associated transcription factor 1; BCL2-associated transcription factor 1; BCLAF1; BCLF1; bK211L9.1; BTF; KIAA0164
Gene Symbols: BCLAF1
Molecular weight: 106,122 Da
Basal Isoelectric point: 9.99  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein