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BCOR
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2). Belongs to the BCOR family. Ubiquitously expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: Xp11.4 |
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Cellular Component:
BCOR complex; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription factor binding; heat shock protein binding; histone deacetylase binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding; transcription corepressor activity; ubiquitin-protein transferase activity
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Biological Process:
blastocyst hatching; chromatin remodeling; heart development; negative regulation of bone mineralization; negative regulation of DNA-templated transcription; negative regulation of tooth mineralization; negative regulation of transcription by RNA polymerase II; odontogenesis; roof of mouth development; specification of axis polarity
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Disease: Microphthalmia, Syndromic 1; Microphthalmia, Syndromic 2
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Reference #:
Q6W2J9
(UniProtKB)
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Alt. Names/Synonyms: 5830466J11Rik; 8430401K06Rik; ANOP2; BCL-6 coreceptor; BCL-6 corepressor; BCL-6 interacting corepressor; BCL6 co-repressor; BCL6 corepressor; BCL6 interacting corepressor; BCOR; FLJ20285; FLJ38041; KIAA1575; MAA2; MCOPS2; MGC131961; MGC71031
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Gene Symbols: BCOR
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Molecular weight:
192,189 Da
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Basal Isoelectric point:
6.06
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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