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SSRP1
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. Belongs to the SSRP1 family. Note: This description may include information from UniProtKB.
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| Protein type: Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor |
| Chromosomal Location of mouse Ortholog: 2 D|2 49.45 cM |
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Cellular Component:
chromosome; FACT complex; nucleus
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Molecular Function:
chromatin binding; DNA binding; histone binding; nucleosome binding
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Biological Process:
DNA damage response; DNA repair; DNA replication; nucleosome assembly; nucleosome disassembly; regulation of chromatin organization
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Reference #:
Q08943
(UniProtKB)
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Alt. Names/Synonyms: C81323; Facilitates chromatin transcription complex subunit SSRP1; FACT complex subunit SSRP1; Hmg1-r; Hmg1-rs1; Hmgi-; Hmgi-rs3; Hmgo; Hmgox; OTTMUSP00000014446; Recombination signal sequence recognition protein 1; Ssrp1; structure specific recognition protein 1; Structure-specific recognition protein 1; T160
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Gene Symbols: Ssrp1
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Molecular weight:
80,860 Da
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Basal Isoelectric point:
6.33
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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