APC5 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC5 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component:  anaphase-promoting complex; cytosol; nucleoplasm; nucleus
Molecular Function:  protein phosphatase binding
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell cycle; cell division; protein K11-linked ubiquitination; regulation of mitotic cell cycle phase transition; ubiquitin-dependent protein catabolic process
Reference #:  Q9UJX4 (UniProtKB)
Alt. Names/Synonyms: ANAPC5; anaphase promoting complex subunit 5; Anaphase-promoting complex subunit 5; APC5; Cyclosome subunit 5
Gene Symbols: ANAPC5
Molecular weight: 85,077 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
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APC5

Protein Structure Not Found.


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