NCAPH2 Regulatory subunit of the condensin-2 complex, a complex that seems to provide chromosomes with an additional level of organization and rigidity and in establishing mitotic chromosome architecture. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of chromatin bridges at anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. Seems to have lineage-specific role in T-cell development. Belongs to the CND2 H2 (condensin-2 subunit 2) family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Endoplasmic reticulum; Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q13.33
Cellular Component:  cell junction; intercellular bridge; nucleoplasm; nucleus
Molecular Function:  protein binding
Biological Process:  female meiosis chromosome separation; mitotic chromosome condensation; T cell differentiation in thymus
Reference #:  Q6IBW4 (UniProtKB)
Alt. Names/Synonyms: 384D8_6; CAPH2; Chromosome-associated protein H2; CNDH2; Condensin-2 complex subunit H2; hCAP-H2; Kleisin-beta; lipase maturation factor 2; LMF2; NCAPH2; Non-SMC condensin II complex subunit H2; TMEM112B; TMEM153; transmembrane protein 112B; transmembrane protein 153
Gene Symbols: NCAPH2
Molecular weight: 68,227 Da
Basal Isoelectric point: 4.66  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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