SSRP1 Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63. Belongs to the SSRP1 family. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 11q12.1
Cellular Component:  chromosome; nucleolus; nucleoplasm
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding
Biological Process:  DNA repair; DNA replication; regulation of signal transduction by p53 class mediator; regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription elongation from RNA polymerase II promoter
Reference #:  Q08945 (UniProtKB)
Alt. Names/Synonyms: Chromatin-specific transcription elongation factor 80 kDa subunit; cisplatin-DNA SSRP; facilitates chromatin remodeling 80 kDa subunit; Facilitates chromatin transcription complex 80 kDa subunit; Facilitates chromatin transcription complex subunit SSRP1; FACT; FACT 80 kDa subunit; FACT complex subunit SSRP1; FACT80; FACTp80; high mobility group box; hSSRP1; Recombination signal sequence recognition protein 1; SSRP1; structure specific recognition protein 1; Structure-specific recognition protein 1; T160
Gene Symbols: SSRP1
Molecular weight: 81,075 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene