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CRF-R1
G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli. Belongs to the G-protein coupled receptor 2 family. Predominantly expressed in the cerebellum, pituitary, cerebral cortex and olfactory lobe. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of rat Ortholog: 10q32.1 |
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Cellular Component:
apical part of cell; dendrite; dendritic spine; membrane; multivesicular body; neuron projection; neuronal cell body; plasma membrane; trans-Golgi network; vesicle
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Molecular Function:
corticotrophin-releasing factor receptor activity; corticotropin-releasing hormone binding; corticotropin-releasing hormone receptor activity; G protein-coupled peptide receptor activity; G protein-coupled receptor activity; G-protein alpha-subunit binding; peptide binding; protein binding; protein-containing complex binding
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; adrenal gland development; behavioral response to cocaine; behavioral response to ethanol; behavioral response to pain; cell surface receptor signaling pathway; cellular response to corticotropin-releasing hormone stimulus; corticotropin secretion; epithelial cell differentiation; fear response; feeding behavior; G protein-coupled receptor signaling pathway; general adaptation syndrome, behavioral process; hormone-mediated signaling pathway; hypothalamus development; locomotory exploration behavior; long-term synaptic potentiation; memory; negative regulation of epinephrine secretion; negative regulation of feeding behavior; negative regulation of neuron apoptotic process; negative regulation of voltage-gated calcium channel activity; neuropeptide signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cAMP-mediated signaling; positive regulation of cytosolic calcium ion concentration; positive regulation of mast cell degranulation; regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway; regulation of corticosterone secretion; regulation of synaptic plasticity; response to electrical stimulus; response to hypoxia; response to immobilization stress; visual learning
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Reference #:
P35353
(UniProtKB)
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Alt. Names/Synonyms: corticotrophin releasing hormone receptor 1; corticotropin releasing hormone 1; corticotropin releasing hormone receptor 1; Corticotropin-releasing factor receptor 1; Corticotropin-releasing hormone receptor 1; CRF-R; CRF-R-1; CRF-R1; CRF1; CRFR-1; CRFR1; CRH-R 1; CRH-R-1; CRH-R1; Crhr; Crhr1
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Gene Symbols: Crhr1
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Molecular weight:
47,842 Da
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Basal Isoelectric point:
9.76
Predict pI for various phosphorylation states
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