ATP1A1 the catalytic component of an integral membrane heterodimeric enzyme with Na,K-ATPase activity. Catalyzes the hydrolysis of ATP coupled with the exchange of Na and K ions across the plasma membrane. This action creates the electrochemical gradient of Na and K, providing the energy for active transport of various nutrients. Belongs to the P-type ATPase family. Four splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 3 F2.2|3 44.3 cM
Cellular Component:  apical plasma membrane; basolateral plasma membrane; caveola; endoplasmic reticulum; endosome; Golgi apparatus; integral component of membrane; intercalated disc; membrane; membrane raft; plasma membrane; postsynaptic density; protein-containing complex; sarcolemma; sodium:potassium-exchanging ATPase complex; T-tubule
Molecular Function:  ADP binding; ankyrin binding; ATP binding; chaperone binding; metal ion binding; nucleotide binding; phosphatase activity; phosphatidylinositol 3-kinase binding; potassium ion binding; potassium-transporting ATPase activity; protein binding; protein domain specific binding; protein kinase binding; sodium ion binding; sodium:potassium-exchanging ATPase activity; steroid hormone binding
Biological Process:  ATP hydrolysis coupled proton transport; ATP hydrolysis coupled transmembrane transport; cellular potassium ion homeostasis; cellular response to mechanical stimulus; cellular response to steroid hormone stimulus; cellular sodium ion homeostasis; ion transport; membrane hyperpolarization; membrane repolarization; negative regulation of glucocorticoid biosynthetic process; negative regulation of heart contraction; positive regulation of heart contraction; positive regulation of striated muscle contraction; potassium ion import across plasma membrane; potassium ion transport; regulation of blood pressure; regulation of cardiac muscle cell contraction; regulation of sodium ion transport; regulation of the force of heart contraction; response to drug; sodium ion export across plasma membrane; sodium ion transport
Reference #:  Q8VDN2 (UniProtKB)
Alt. Names/Synonyms: AT1A1; Atp1a1; Atpa-1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; BC010319; MGC38419; Na(+)/K(+) ATPase alpha-1 subunit; OTTMUSP00000017686; Sodium pump subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-1
Gene Symbols: Atp1a1
Molecular weight: 112,982 Da
Basal Isoelectric point: 5.3  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene