MYO6 Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. May play a role in the extension and network organization of neurites. Required for structural integrity of inner ear hair cells. Modulates RNA polymerase II-dependent transcription. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Expressed in most tissues examined including heart, brain, placenta, pancreas, spleen, thymus, prostate, testis, ovary, small intestine and colon. Highest levels in brain, pancreas, testis and small intestine. Also expressed in fetal brain and cochlea. Isoform 1 and isoform 2, containing the small insert, and isoform 4, containing neither insert, are expressed in unpolarized epithelial cells. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 9 E1|9 43.98 cM
Cellular Component:  apical part of cell; axon; brush border; cell projection; clathrin-coated pit; cochlear hair cell ribbon synapse; cytoplasm; cytoplasmic vesicle; endocytic vesicle; filamentous actin; glutamatergic synapse; Golgi apparatus; intracellular membrane-bounded organelle; membrane; microvillus; myosin complex; neuronal cell body; nuclear membrane; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic actin cytoskeleton; postsynaptic density; presynaptic endocytic zone; protein-containing complex; RNA polymerase II, holoenzyme; ruffle; ruffle membrane; Schaffer collateral - CA1 synapse; synapse; vesicle membrane
Molecular Function:  actin binding; actin filament binding; ATP binding; calmodulin binding; cargo receptor activity; identical protein binding; motor activity; nucleotide binding; protein binding
Biological Process:  cellular response to electrical stimulus; chemical synaptic transmission; dendrite development; DNA damage response, signal transduction by p53 class mediator; endocytosis; glutamate secretion; inner ear auditory receptor cell differentiation; inner ear development; inner ear morphogenesis; locomotory behavior; positive regulation of transcription by RNA polymerase II; postsynaptic neurotransmitter receptor internalization; protein targeting; protein transport; regulation of secretion; regulation of synaptic plasticity; regulation of synaptic vesicle exocytosis; response to drug; sensory perception of sound; synapse assembly
Reference #:  Q64331 (UniProtKB)
Alt. Names/Synonyms: BC029719; Myo6; Myo6<; Myo6<rsv>; myosin VI; Myosin-VI; OTTMUSP00000019172; rsv; Snell's waltzer; Sv; tailchaser; Tlc; Unconventional myosin-6; Unconventional myosin-VI
Gene Symbols: Myo6
Molecular weight: 146,409 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene