ataxin-1 Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development. Belongs to the ATXN1 family. Widely expressed throughout the body. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear export; RNA-binding
Chromosomal Location of Human Ortholog: 13 A5|13 21.98 cM
Cellular Component:  cytoplasm; cytosol; nuclear inclusion body; nuclear matrix; nucleolus; nucleoplasm; nucleus; protein-containing complex
Molecular Function:  chromatin binding; DNA binding; identical protein binding; poly(G) binding; poly(U) RNA binding; protein binding; protein C-terminus binding; protein self-association; RNA binding
Biological Process:  adult locomotory behavior; anatomical structure development; brain development; excitatory postsynaptic potential; learning; lung alveolus development; memory; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; nervous system development; nuclear export; positive regulation of glial cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; social behavior; visual learning
Reference #:  P54254 (UniProtKB)
Alt. Names/Synonyms: ataxin 1; Ataxin-1; Atx1; Atxn1; C85907; Sca1; spinocerebellar ataxia 1 homolog; Spinocerebellar ataxia type 1 protein homolog
Gene Symbols: Atxn1
Molecular weight: 83,793 Da
Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene