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ataxin-1
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development. Belongs to the ATXN1 family. Widely expressed throughout the body. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear export; RNA-binding |
| Chromosomal Location of mouse Ortholog: 13 A5|13 21.98 cM |
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Cellular Component:
cytoplasm; cytosol; nuclear inclusion body; nuclear matrix; nucleolus; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
chromatin binding; DNA binding; identical protein binding; poly(G) binding; poly(U) RNA binding; protein binding; protein self-association; RNA binding
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Biological Process:
adult locomotory behavior; brain development; excitatory postsynaptic potential; insulin-like growth factor receptor signaling pathway; learning; lung alveolus development; memory; negative regulation of DNA-templated transcription; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of phosphorylation; negative regulation of transcription by RNA polymerase II; nervous system development; nuclear export; phosphorylation; positive regulation of glial cell proliferation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; social behavior; transcription by RNA polymerase II; visual learning
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Reference #:
P54254
(UniProtKB)
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Alt. Names/Synonyms: 2900016G23Rik; ataxin 1; Ataxin-1; Atx; Atx1; Atxn1; C85907; Gm10786; Sca1; spinocerebellar ataxia 1 homolog; Spinocerebellar ataxia type 1 protein homolog
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Gene Symbols: Atxn1
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Molecular weight:
83,793 Da
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Basal Isoelectric point:
8.29
Predict pI for various phosphorylation states
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CST Pathways:
PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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