ataxin-1 Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development. Belongs to the ATXN1 family. Widely expressed throughout the body. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear export; RNA-binding
Chromosomal Location of human Ortholog: 6p22.3
Cellular Component:  cytoplasm; cytosol; nuclear inclusion body; nuclear matrix; nucleolus; nucleoplasm; nucleus
Molecular Function:  DNA binding; identical protein binding; poly(G) binding; poly(U) RNA binding; protein binding; protein C-terminus binding; protein self-association
Biological Process:  anatomical structure development; brain development; learning; memory; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; nervous system development; nuclear export; regulation of DNA-templated transcription; RNA processing; social behavior
Disease: Spinocerebellar Ataxia 1
Reference #:  P54253 (UniProtKB)
Alt. Names/Synonyms: alternative ataxin1; ataxin 1; Ataxin-1; ATX1; ATXN1; D6S504E; SCA1; Spinocerebellar ataxia type 1 protein
Gene Symbols: ATXN1
Molecular weight: 86,923 Da
Basal Isoelectric point: 8.49  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein