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ataxin-1
Chromatin-binding factor that repress Notch signaling in the absence of Notch intracellular domain by acting as a CBF1 corepressor. Binds to the HEY promoter and might assist, along with NCOR2, RBPJ-mediated repression. Binds RNA in vitro. May be involved in RNA metabolism. In concert with CIC and ATXN1L, involved in brain development. Belongs to the ATXN1 family. Widely expressed throughout the body. 1 alternatively spliced human isoform has been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear export; RNA-binding |
| Chromosomal Location of human Ortholog: 6p22.3 |
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Cellular Component:
cytoplasm; cytosol; nuclear inclusion body; nuclear matrix; nucleolus; nucleoplasm; nucleus
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Molecular Function:
DNA binding; identical protein binding; poly(G) binding; poly(U) RNA binding; protein binding; protein self-association
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Biological Process:
brain development; learning; memory; negative regulation of DNA-templated transcription; negative regulation of transcription by RNA polymerase II; nervous system development; nuclear export; RNA processing; social behavior
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Disease: Spinocerebellar Ataxia 1
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Reference #:
P54253
(UniProtKB)
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Alt. Names/Synonyms: alternative ataxin1; ataxin 1; Ataxin-1; ATX1; ATXN1; D6S504E; SCA1; Spinocerebellar ataxia type 1 protein
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Gene Symbols: ATXN1
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Molecular weight:
86,923 Da
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Basal Isoelectric point:
8.49
Predict pI for various phosphorylation states
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CST Pathways:
PI3K/Akt Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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