OMA1
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. Belongs to the peptidase M48 family. Widely expressed, with strong expression in the heart, skeletal muscle, kidney and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: EC 3.4.24.-; Membrane protein, integral; Membrane protein, multi-pass; Protease |
Chromosomal Location of human Ortholog: 1p32.2-p32.1 |
Cellular Component:
mitochondrial inner membrane; mitochondrial membrane
|
Molecular Function:
lipid binding; metal ion binding; metalloendopeptidase activity
|
Biological Process:
cristae formation; diet induced thermogenesis; energy homeostasis; glucose metabolic process; HRI-mediated signaling; integrated stress response signaling; lipid metabolic process; mitochondrial protein processing; mitochondrial respiratory chain complex assembly; negative regulation of mitochondrial fusion; positive regulation of apoptotic process; positive regulation of cold-induced thermogenesis; protein autoprocessing; protein quality control for misfolded or incompletely synthesized proteins; regulation of apoptotic process; regulation of cristae formation; zymogen activation
|
Reference #:
Q96E52
(UniProtKB)
|
Alt. Names/Synonyms: 2010001O09Rik; DAB1; FLJ33782; Metalloendopeptidase OMA1, mitochondrial; metalloprotease related protein 1; Metalloprotease-related protein 1; MPRP-1; MPRP1; OMA1; OMA1 homolog, zinc metallopeptidase; OMA1 homolog, zinc metallopeptidase (S. cerevisiae); OMA1 zinc metallopeptidase; OMA1 zinc metallopeptidase homolog; overlapping activity with M-AAA protease; Overlapping with the m-AAA protease 1 homolog; peptidase; YKR087C; zinc metallopeptidase OMA1; ZMPOMA1
|
Gene Symbols: OMA1
|
Molecular weight:
60,120 Da
|
Basal Isoelectric point:
9.36
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|