ONECUT1 Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Belongs to the CUT homeobox family. Highly expressed in liver; lower expression in testis and skin. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 15q21.3
Cellular Component: 
Molecular Function:  DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific
Biological Process:  anatomical structure morphogenesis; B cell differentiation; cell fate commitment; cilium assembly; endocrine pancreas development; endoderm development; epithelial cell development; glucose metabolic process; liver development; negative regulation of transforming growth factor beta receptor signaling pathway; Notch signaling pathway; positive regulation of cell migration; positive regulation of transcription by RNA polymerase II; regulation of cell-matrix adhesion; regulation of transcription, DNA-templated; spleen development
Reference #:  Q9UBC0 (UniProtKB)
Alt. Names/Synonyms: Hepatocyte nuclear factor 6; hepatocyte nuclear factor 6, alpha; HNF-6; HNF6; HNF6A; One cut domain family member 1; one cut domain, family member 1; One cut homeobox 1; ONECUT1
Gene Symbols: ONECUT1
Molecular weight: 51,023 Da
Basal Isoelectric point: 9.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB