ONECUT1
Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription. Belongs to the CUT homeobox family. Highly expressed in liver; lower expression in testis and skin. Note: This description may include information from UniProtKB.
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Protein type: DNA-binding |
Chromosomal Location of human Ortholog: 15q21.3 |
Cellular Component:
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Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific
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Biological Process:
anatomical structure morphogenesis; B cell differentiation; cell fate commitment; cilium assembly; endocrine pancreas development; endoderm development; epithelial cell development; glucose metabolic process; liver development; negative regulation of transforming growth factor beta receptor signaling pathway; Notch signaling pathway; positive regulation of cell migration; positive regulation of transcription by RNA polymerase II; regulation of cell-matrix adhesion; regulation of transcription, DNA-templated; spleen development
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Reference #:
Q9UBC0
(UniProtKB)
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Alt. Names/Synonyms: Hepatocyte nuclear factor 6; hepatocyte nuclear factor 6, alpha; HNF-6; HNF6; HNF6A; One cut domain family member 1; one cut domain, family member 1; One cut homeobox 1; ONECUT1
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Gene Symbols: ONECUT1
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Molecular weight:
51,023 Da
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Basal Isoelectric point:
9.71
Predict pI for various phosphorylation states
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