NOG Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6. Belongs to the noggin family. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 17q22
Cellular Component:  extracellular region; extracellular space
Molecular Function:  cytokine binding; protein binding; protein homodimerization activity
Biological Process:  atrial cardiac muscle tissue morphogenesis; axial mesoderm development; BMP signaling pathway; BMP signaling pathway involved in heart development; cartilage development; cell differentiation in hindbrain; dorsal/ventral pattern formation; embryonic digit morphogenesis; embryonic skeletal joint morphogenesis; embryonic skeletal system development; endocardial cushion morphogenesis; endoderm formation; epithelial to mesenchymal transition; face morphogenesis; fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; heart trabecula morphogenesis; in utero embryonic development; limb development; lung morphogenesis; membranous septum morphogenesis; mesoderm formation; middle ear morphogenesis; motor neuron axon guidance; negative regulation of apoptotic signaling pathway; negative regulation of astrocyte differentiation; negative regulation of BMP signaling pathway; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle cell proliferation; negative regulation of cartilage development; negative regulation of cell migration; negative regulation of cytokine activity; negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; negative regulation of osteoblast differentiation; negative regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of transcription by RNA polymerase II; nervous system development; neural plate morphogenesis; neural tube closure; notochord morphogenesis; osteoblast differentiation; outflow tract morphogenesis; pharyngeal arch artery morphogenesis; pituitary gland development; positive regulation of branching involved in ureteric bud morphogenesis; positive regulation of epithelial cell proliferation; positive regulation of gene expression; positive regulation of glomerulus development; positive regulation of transcription by RNA polymerase II; prostatic bud formation; regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation; skeletal system development; somatic stem cell population maintenance; somite development; spinal cord development; ureteric bud formation; ventricular compact myocardium morphogenesis; ventricular septum morphogenesis; wound healing
Disease: Brachydactyly, Type B2; Multiple Synostoses Syndrome 1; Stapes Ankylosis With Broad Thumb And Toes; Symphalangism, Proximal, 1a; Tarsal-carpal Coalition Syndrome
Reference #:  Q13253 (UniProtKB)
Alt. Names/Synonyms: NOG; NOGG; Noggin; SYM1; symphalangism 1 (proximal); SYNS1
Gene Symbols: NOG
Molecular weight: 25,774 Da
Basal Isoelectric point: 9.13  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene