KCNK3 pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 6q14
Cellular Component:  integral component of membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  ion channel activity; open rectifier potassium channel activity; potassium ion leak channel activity; protein binding; protein C-terminus binding; S100 protein binding
Biological Process:  brain development; cellular response to hypoxia; cellular response to zinc ion; cochlea development; ion transmembrane transport; negative regulation of cytosolic calcium ion concentration; potassium ion transmembrane transport; potassium ion transport; response to drug; stabilization of membrane potential
Reference #:  O54912 (UniProtKB)
Alt. Names/Synonyms: Acid-sensitive potassium channel protein TASK-1; Kcnk3; Potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; rTASK; Task; Task-1; Task1; TWIK-related acid-sensitive K(+) channel 1; TWIK-related acid-sensitive K+ channel; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1
Gene Symbols: Kcnk3
Molecular weight: 45,276 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene