KCNK3 pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5 B1|5 16.68 cM
Cellular Component:  extracellular space; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  growth factor activity; ion channel activity; open rectifier potassium channel activity; potassium channel activity; potassium ion leak channel activity; protein C-terminus binding; protein heterodimerization activity; protein homodimerization activity
Biological Process:  ion transport; potassium ion transport; reduction of cytosolic calcium ion concentration; response to drug; stabilization of membrane potential; transport
Reference #:  O35111 (UniProtKB)
Alt. Names/Synonyms: Acid-sensitive potassium channel protein TASK-1; Cardiac two pore background K(+) channel; Ctbak; cTBAK-1; Kcnk3; Potassium channel subfamily K member 3; potassium channel, subfamily K, member 3; Task; Task1; TWIK-related acid-sensitive K(+) channel 1; Two pore K(+) channel KT3.1; Two pore potassium channel KT3.1
Gene Symbols: Kcnk3
Molecular weight: 45,068 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene