MC4R Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). Belongs to the G-protein coupled receptor 1 family. Brain, placental, and gut tissues. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 18|18 E1
Cellular Component:  integral component of membrane; membrane; nucleus; plasma membrane
Molecular Function:  G protein-coupled receptor activity; hormone binding; melanocortin receptor activity; melanocyte-stimulating hormone receptor activity; neuropeptide binding; peptide hormone binding; protein binding; ubiquitin protein ligase binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; diet induced thermogenesis; energy reserve metabolic process; feeding behavior; G protein-coupled receptor signaling pathway; insulin secretion; negative regulation of feeding behavior; positive regulation of bone resorption; regulation of feeding behavior; regulation of grooming behavior; regulation of metabolic process; response to insulin; signal transduction
Reference #:  P56450 (UniProtKB)
Alt. Names/Synonyms: Fatb; Fatboy; Glu3; MC4-R; Mc4r; melanocortin 4 receptor; Melanocortin receptor 4; Pkcp
Gene Symbols: Mc4r
Molecular weight: 36,959 Da
Basal Isoelectric point: 7.14  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene