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Calnexin
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. Belongs to the calreticulin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 11 B1.3|11 30.46 cM |
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Cellular Component:
axon; dendrite cytoplasm; dendritic spine; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; glutamatergic synapse; lumenal side of endoplasmic reticulum membrane; membrane; mitochondria-associated endoplasmic reticulum membrane; neuronal cell body; nuclear membrane; postsynaptic membrane; presynapse; presynaptic active zone membrane; protein-containing complex; ribosome; smooth endoplasmic reticulum; synapse
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Molecular Function:
apolipoprotein binding; calcium ion binding; carbohydrate binding; ionotropic glutamate receptor binding; metal ion binding; protein binding; unfolded protein binding
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Biological Process:
clathrin-dependent endocytosis; protein folding; synaptic vesicle endocytosis; ubiquitin-dependent ERAD pathway
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Reference #:
P35564
(UniProtKB)
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Alt. Names/Synonyms: 1110069N15Rik; AI988026; Calnexin; CALX; Canx; Cnx; D11Ertd153e; OTTMUSP00000005744
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Gene Symbols: Canx
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Molecular weight:
67,278 Da
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Basal Isoelectric point:
4.5
Predict pI for various phosphorylation states
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