Calnexin Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. Belongs to the calreticulin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 5q35.3
Cellular Component:  axon; dendrite cytoplasm; dendritic spine; endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; glutamatergic synapse; integral component of lumenal side of endoplasmic reticulum membrane; integral component of postsynaptic membrane; integral component of presynaptic active zone membrane; melanosome; Mitochondria-associated ER Membrane; neuronal cell body; ribosome; rough endoplasmic reticulum; smooth endoplasmic reticulum
Molecular Function:  apolipoprotein binding; calcium ion binding; carbohydrate binding; ionotropic glutamate receptor binding; protein binding; unfolded protein binding
Biological Process:  aging; antigen processing and presentation of exogenous peptide antigen via MHC class II; antigen processing and presentation of peptide antigen via MHC class I; clathrin-dependent endocytosis; interleukin-27-mediated signaling pathway; interleukin-35-mediated signaling pathway; protein folding; protein folding in endoplasmic reticulum; protein secretion; synaptic vesicle endocytosis
Reference #:  P27824 (UniProtKB)
Alt. Names/Synonyms: Calnexin; CALX; CANX; CNX; epididymis secretory sperm binding protein; FLJ26570; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
Gene Symbols: CANX
Molecular weight: 67,568 Da
Basal Isoelectric point: 4.47  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein