Calnexin
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. Belongs to the calreticulin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis |
Chromosomal Location of human Ortholog: 5q35.3 |
Cellular Component:
endoplasmic reticulum; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum quality control compartment; extracellular exosome; lumenal side of endoplasmic reticulum membrane; melanosome; mitochondria-associated endoplasmic reticulum membrane; nuclear membrane; presynapse
|
Molecular Function:
calcium ion binding; carbohydrate binding; protein binding; unfolded protein binding
|
Biological Process:
clathrin-dependent endocytosis; protein folding; protein folding in endoplasmic reticulum; protein secretion; synaptic vesicle endocytosis; ubiquitin-dependent ERAD pathway; viral protein processing
|
Reference #:
P27824
(UniProtKB)
|
Alt. Names/Synonyms: Calnexin; CALX; CANX; CNX; epididymis secretory sperm binding protein; FLJ26570; IP90; Major histocompatibility complex class I antigen-binding protein p88; p90
|
Gene Symbols: CANX
|
Molecular weight:
67,568 Da
|
Basal Isoelectric point:
4.47
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|