MYPT1 Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. Expressed in striated muscles, specifically in type 2a fibers (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 7q21
Cellular Component:  A band; actin cytoskeleton; centrosome; contractile fiber; cytoplasm; cytosol; kinetochore; PTW/PP1 phosphatase complex; Z disc
Molecular Function:  14-3-3 protein binding; enzyme inhibitor activity; phosphatase regulator activity; phosphoprotein phosphatase activity; protein binding; protein kinase binding
Biological Process:  cellular response to drug; centrosome cycle; mitotic cell cycle; negative regulation of catalytic activity; positive regulation of myosin-light-chain-phosphatase activity; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; regulation of catalytic activity; regulation of cell adhesion; regulation of myosin-light-chain-phosphatase activity; regulation of nucleocytoplasmic transport; signal transduction
Reference #:  Q10728 (UniProtKB)
Alt. Names/Synonyms: M110; Mbs; MBSP; Myosin phosphatase target subunit 1; myosin phosphatase, target subunit 1; Myosin phosphatase-targeting subunit 1; Mypt1; PP-1M; Ppp1r12a; Protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; Protein phosphatase myosin-binding subunit; Protein phosphatase subunit 1M; Serine/threonine protein phosphatase PP1 smooth muscle regulatory subunit M110; smooth muscle myosin phosphatase myosin-binding subunit
Gene Symbols: Ppp1r12a
Molecular weight: 115,283 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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MYPT1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene