PDE4B Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. Expressed in brain, heart, lung and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of rat Ortholog: 5q33
Cellular Component:  cell periphery; centrosome; cytosol; dendritic spine; excitatory synapse; gamma-tubulin complex; membrane; nucleus; perinuclear region of cytoplasm; postsynaptic density; synaptic vesicle; voltage-gated calcium channel complex; Z disc
Molecular Function:  3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; gamma-tubulin binding; hydrolase activity; metal ion binding; transmembrane transporter binding
Biological Process:  cAMP catabolic process; cellular response to epinephrine stimulus; cellular response to lipopolysaccharide; cellular response to xenobiotic stimulus; leukocyte migration; negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process; negative regulation of relaxation of cardiac muscle; neutrophil chemotaxis; neutrophil homeostasis; positive regulation of interleukin-2 production; positive regulation of type II interferon production; regulation of cardiac muscle cell contraction; regulation of high voltage-gated calcium channel activity; signal transduction; smooth muscle contraction; T cell receptor signaling pathway
Reference #:  P14646 (UniProtKB)
Alt. Names/Synonyms: 3',5'-cyclic AMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; DPDE4; MGC93193; PDE4/IVb; Pde4b; Pde4B1; Pde4B2; Pde4B3; Pde4B4; Phosphodiesterase 4B cAMP-specific (dunce; phosphodiesterase 4B, cAMP specific; Phosphodiesterase 4B, cAMP-specific (dunce
Gene Symbols: Pde4b
Molecular weight: 83,375 Da
Basal Isoelectric point: 5.07  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene