MRPL27 a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Protein type: Mitochondrial; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 17q21.33
Cellular Component:  mitochondrial inner membrane; mitochondrial large ribosomal subunit
Molecular Function:  protein binding; RNA binding; structural constituent of ribosome
Biological Process:  translation
Reference #:  Q9P0M9 (UniProtKB)
Alt. Names/Synonyms: 39S ribosomal protein L27, mitochondrial; L27mt; MGC23716; mitochondrial ribosomal protein L27; MRP-L27; MRPL27; RM27
Gene Symbols: MRPL27
Molecular weight: 16,073 Da
Basal Isoelectric point: 10.42  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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