MMRN2
Inhibits endothelial cells motility and acts as a negative regulator of angiogenesis; it downregulates KDR activation by binding VEGFA. Endothelium. Note: This description may include information from UniProtKB.
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Protein type: Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 10q23.2 |
Cellular Component:
basement membrane; collagen-containing extracellular matrix; extracellular space; multimerin complex
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Molecular Function:
extracellular matrix structural constituent; protein binding
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Biological Process:
cell adhesion; cell migration involved in sprouting angiogenesis; negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; negative regulation of cell migration; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of cell population proliferation; negative regulation of vascular endothelial growth factor receptor signaling pathway; positive regulation of defense response to bacterium; positive regulation of epithelial tube formation; positive regulation of morphogenesis of an epithelium
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Reference #:
Q9H8L6
(UniProtKB)
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Alt. Names/Synonyms: Elastin microfibril interface located protein 3; Elastin microfibril interfacer 3; EMILIN-3; EMILIN-like protein EndoGlyx-1; EMILIN3; EndoGlyx-1; EndoGlyx-1 p125/p140 subunit; FLJ13465; MMRN2; multimerin 2; Multimerin-2
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Gene Symbols: MMRN2
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Molecular weight:
104,409 Da
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Basal Isoelectric point:
5.56
Predict pI for various phosphorylation states
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