MLSTD2
Catalyzes the reduction of saturated and unsaturated C16 or C18 fatty acyl-CoA to fatty alcohols. It plays an essential role in the production of ether lipids/plasmalogens which synthesis requires fatty alcohols. In parallel, it is also required for wax monoesters production since fatty alcohols also constitute a substrate for their synthesis. Belongs to the fatty acyl-CoA reductase family. Note: This description may include information from UniProtKB.
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Protein type: EC 1.2.1.n2; Membrane protein, integral; Oxidoreductase |
Chromosomal Location of human Ortholog: 11p15.3 |
Cellular Component:
peroxisomal membrane; peroxisome
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Molecular Function:
alcohol-forming long-chain fatty acyl-CoA reductase activity; alcohol-forming very long-chain fatty acyl-CoA reductase activity; oxidoreductase activity; protein binding
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Biological Process:
ether lipid biosynthetic process; glycerophospholipid biosynthetic process; long-chain fatty-acyl-CoA metabolic process; wax biosynthetic process
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Disease: Cataracts, Spastic Paraparesis, And Speech Delay; Peroxisomal Fatty Acyl-coa Reductase 1 Disorder
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Reference #:
Q8WVX9
(UniProtKB)
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Alt. Names/Synonyms: DKFZp686A0370; DKFZp686P18247; FACR1; FAR1; fatty acyl CoA reductase 1; Fatty acyl-CoA reductase 1; FLJ22728; FLJ33561; male sterility domain containing 2; Male sterility domain-containing protein 2; MLSTD2; PFCRD; putative fatty acyl reductase; SDR10E1; short chain dehydrogenase/reductase family 10E, member 1
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Gene Symbols: FAR1
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Molecular weight:
59,357 Da
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Basal Isoelectric point:
9.25
Predict pI for various phosphorylation states
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