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5-HT(2C)
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress. Plays a role in insulin sensitivity and glucose homeostasis. Belongs to the G-protein coupled receptor 1 family. Detected in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: Xq23 |
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Cellular Component:
integral component of plasma membrane; plasma membrane
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Molecular Function:
1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; drug binding; G protein-coupled serotonin receptor activity; Gq/11-coupled serotonin receptor activity; serotonin binding
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Biological Process:
behavioral fear response; cellular calcium ion homeostasis; cGMP-mediated signaling; feeding behavior; G protein-coupled receptor signaling pathway; locomotory behavior; phospholipase C-activating G protein-coupled receptor signaling pathway; phospholipase C-activating serotonin receptor signaling pathway; positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of fat cell differentiation; positive regulation of phosphatidylinositol biosynthetic process; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of neurological system process; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway
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Reference #:
P28335
(UniProtKB)
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Alt. Names/Synonyms: 5-HT(2C); 5-HT-1C; 5-HT-2C; 5-HT1C; 5-HT2C; 5-HTR2C; 5-hydroxytryptamine (serotonin) receptor 2C; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled; 5-hydroxytryptamine receptor 1C; 5-hydroxytryptamine receptor 2C; 5HT2C; 5HTR2C; HTR1C; HTR2C; serotonin 5-HT-1C receptor; serotonin 5-HT-2C receptor; Serotonin receptor 2C
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Gene Symbols: HTR2C
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Molecular weight:
51,805 Da
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Basal Isoelectric point:
9.17
Predict pI for various phosphorylation states
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