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MC5R
Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. Belongs to the G-protein coupled receptor 1 family. Expressed in the brain but not in the melanoma cells. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 18p11.21 |
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Cellular Component:
cytoplasm; plasma membrane
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Molecular Function:
hormone binding; melanocortin receptor activity; protein binding
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; regulation of metabolic process
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Reference #:
P33032
(UniProtKB)
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Alt. Names/Synonyms: MC-2; MC2; MC5-R; MC5R; melanocortin 5 receptor; Melanocortin receptor 5
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Gene Symbols: MC5R
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Molecular weight:
36,601 Da
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Basal Isoelectric point:
8.75
Predict pI for various phosphorylation states
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