MAGE-L2 Probably enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Acts as a regulator of retrograde transport via its interaction with VPS35. Recruited to retromer-containing endosomes and promotes the formation of 'Lys-63'-linked polyubiquitin chains at 'Lys-220' of WASHC1 together with TRIM27, leading to promote endosomal F-actin assembly. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Significantly promotes the cytoplasmic accumulation of CLOCK. Expressed in placenta, fetal and adult brain. Not detected in heart and small intestine, very low levels in fibroblasts. Not expressed in brain of a Prader-Willi patient. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 15q11.2
Cellular Component:  cytosol; early endosome; endosome; nucleus
Molecular Function:  protein binding; ubiquitin-protein transferase activity
Biological Process:  Arp2/3 complex-mediated actin nucleation; negative regulation of transcription, DNA-templated; positive regulation of actin nucleation; protein K63-linked ubiquitination; regulation of circadian rhythm; retrograde transport, endosome to Golgi; rhythmic process
Disease: Prader-willi Syndrome; Prader-willi-like Syndrome
Reference #:  Q9UJ55 (UniProtKB)
Alt. Names/Synonyms: MAGE family member L2; MAGE-L2; MAGE-like 2; MAGE-like protein 2; MAGEL2; MAGL2; melanoma antigen family L2; NDNL1; Necdin-like protein 1; nM15; Protein nM15; PWLS; SHFYNG
Gene Symbols: MAGEL2
Molecular weight: 132,822 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein