MAGE-L2 May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Interacts with TRIM27.
Chromosomal Location of Human Ortholog: 15q11.2
Cellular Component:  cytosol; early endosome; endosome; nucleus
Molecular Function:  protein binding; ubiquitin-protein transferase activity
Biological Process:  Arp2/3 complex-mediated actin nucleation; negative regulation of transcription, DNA-templated; positive regulation of actin nucleation; protein K63-linked ubiquitination; regulation of circadian rhythm; retrograde transport, endosome to Golgi; rhythmic process
Disease: Prader-willi Syndrome; Prader-willi-like Syndrome
Reference #:  Q9UJ55 (UniProtKB)
Alt. Names/Synonyms: MAGE-like 2; MAGE-like protein 2; MAGEL2; MAGL2; NDNL1; Necdin-like protein 1; nM15; Protein nM15
Gene Symbols: MAGEL2
Molecular weight: 132,822 Da
Basal Isoelectric point: 9.55  Predict pI for various phosphorylation states
Select Structure to View Below

MAGE-L2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein