LSM4 Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Spliceosome
Chromosomal Location of human Ortholog: 19p13.11
Cellular Component:  cytosol; Lsm2-8 complex; membrane; nucleoplasm; nucleus; P-body; protein-containing complex; spliceosomal tri-snRNP complex; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; U6 snRNP
Molecular Function:  PH domain binding; protein binding; RNA binding; U6 snRNA binding
Biological Process:  mRNA splicing, via spliceosome; nuclear-transcribed mRNA catabolic process; P-body assembly; RNA splicing; spliceosomal snRNP assembly
Reference #:  Q9Y4Z0 (UniProtKB)
Alt. Names/Synonyms: Glycine-rich protein; GRP; LSM4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated; LSM4 homolog, U6 small nuclear RNA associated; LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); LSM4 U6 small nuclear RNA and mRNA degradation associated; U6 snRNA-associated Sm-like protein LSm4; YER112W
Gene Symbols: LSM4
Molecular weight: 15,350 Da
Basal Isoelectric point: 10.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene