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LSM4
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. Belongs to the snRNP Sm proteins family. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding; Spliceosome |
| Chromosomal Location of human Ortholog: 19p13.11 |
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Cellular Component:
cytosol; Lsm2-8 complex; membrane; nucleoplasm; nucleus; P-body; protein-containing complex; spliceosomal tri-snRNP complex; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; U6 snRNP
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Molecular Function:
PH domain binding; protein binding; RNA binding; U6 snRNA binding
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Biological Process:
mRNA splicing, via spliceosome; nuclear-transcribed mRNA catabolic process; P-body assembly; RNA splicing; spliceosomal snRNP assembly
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Reference #:
Q9Y4Z0
(UniProtKB)
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Alt. Names/Synonyms: Glycine-rich protein; GRP; LSM4; LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated; LSM4 homolog, U6 small nuclear RNA associated; LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); LSM4 U6 small nuclear RNA and mRNA degradation associated; U6 snRNA-associated Sm-like protein LSm4; YER112W
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Gene Symbols: LSM4
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Molecular weight:
15,350 Da
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Basal Isoelectric point:
10.02
Predict pI for various phosphorylation states
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