LRRC32 Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). Belongs to the LRRC32/LRRC33 family. Preferentially expressed in regulatory T-cells (Tregs). Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component:  cell surface; integral component of plasma membrane; nucleoplasm
Molecular Function:  protein binding; transforming growth factor beta binding
Biological Process:  negative regulation of activated T cell proliferation; negative regulation of cytokine secretion; positive regulation of gene expression; regulation of transforming growth factor beta activation; regulation of transforming growth factor beta3 activation; secondary palate development; transforming growth factor beta receptor signaling pathway
Disease: Cleft Palate, Proliferative Retinopathy, And Developmental Delay
Reference #:  Q14392 (UniProtKB)
Alt. Names/Synonyms: D11S833E; GARP; Garpin; Glycoprotein A repetitions predominant; leucine rich repeat containing 32; Leucine-rich repeat-containing protein 32; LRC32; LRRC32; Transforming growth factor beta activator LRRC32
Gene Symbols: LRRC32
Molecular weight: 71,979 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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LRRC32

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene