LILRA4 Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of human Ortholog: 19q13.42
Cellular Component:  Fc-epsilon receptor I complex; plasma membrane
Molecular Function:  coreceptor activity; inhibitory MHC class I receptor activity; protein binding; signaling receptor binding
Biological Process:  cytokine-mediated signaling pathway; Fc-epsilon receptor signaling pathway; innate immune response; negative regulation of interferon-alpha production; negative regulation of toll-like receptor 7 signaling pathway; negative regulation of toll-like receptor 9 signaling pathway; negative regulation of tumor necrosis factor production
Reference #:  P59901 (UniProtKB)
Alt. Names/Synonyms: CD85 antigen-like family member G; CD85g; ILT-7; ILT7; Immunoglobulin-like transcript 7; leucocyte Ig-like receptor A4; leukocyte immunoglobulin like receptor A4; Leukocyte immunoglobulin-like receptor subfamily A member 4; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4; leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 4; LILRA4; LIRA4; MGC129597; MGC129598
Gene Symbols: LILRA4
Molecular weight: 55,181 Da
Basal Isoelectric point: 8.29  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene