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LGR5
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. Belongs to the G-protein coupled receptor 1 family. Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 12q21.1 |
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Cellular Component:
Golgi apparatus; nucleoplasm; plasma membrane; trans-Golgi network membrane
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Molecular Function:
G protein-coupled peptide receptor activity; G protein-coupled receptor activity; protein binding; protein-hormone receptor activity; transmembrane signaling receptor activity
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Biological Process:
activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; epithelial cell proliferation involved in renal tubule morphogenesis; G protein-coupled receptor signaling pathway; hair follicle development; inner ear development; oocyte differentiation; positive regulation of canonical Wnt signaling pathway; regulation of cell population proliferation
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Reference #:
O75473
(UniProtKB)
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Alt. Names/Synonyms: FEX; G protein-coupled receptor 49; G protein-coupled receptor 67; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; GPR49; GPR67; GRP49; HG38; leucine rich repeat containing G protein-coupled receptor 5; leucine-rich repeat-containing G protein-coupled receptor 5; Leucine-rich repeat-containing G-protein coupled receptor 5; LGR5; MGC117008; orphan G protein-coupled receptor HG38
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Gene Symbols: LGR5
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Molecular weight:
99,998 Da
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Basal Isoelectric point:
6.12
Predict pI for various phosphorylation states
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