KLHL7 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination. Widely expressed, with highest levels in adult and fetal heart, CNS and adult testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 7p15.3
Cellular Component:  Cul3-RING ubiquitin ligase complex; cytosol; nucleolus; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  identical protein binding; protein binding; protein homodimerization activity
Biological Process:  protein ubiquitination
Disease: Cold-induced Sweating Syndrome 3; Retinitis Pigmentosa 42
Reference #:  Q8IXQ5 (UniProtKB)
Alt. Names/Synonyms: kelch-like 6; kelch-like 7 (Drosophila); Kelch-like protein 7; kelch/BTB; KLHL6; KLHL7; SBBI26
Gene Symbols: KLHL7
Molecular weight: 65,992 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
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KLHL7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB