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JMJD2D
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Belongs to the JHDM3 histone demethylase family. Note: This description may include information from UniProtKB.
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| Protein type: Demethylase; EC 1.14.11.-; Oxidoreductase |
| Chromosomal Location of human Ortholog: 11q21 |
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Cellular Component:
chromatin; nucleoplasm; nucleus; pericentric heterochromatin; site of double-strand break
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Molecular Function:
chromatin DNA binding; damaged DNA binding; histone demethylase activity; histone H3K9 demethylase activity; histone H3K9me2/H3K9me3 demethylase activity; metal ion binding; protein binding
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Biological Process:
cellular response to ionizing radiation; chromatin remodeling; double-strand break repair via homologous recombination; positive regulation of chromatin binding; positive regulation of double-strand break repair via nonhomologous end joining; regulation of gene expression; regulation of protein phosphorylation
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Reference #:
Q6B0I6
(UniProtKB)
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Alt. Names/Synonyms: [histone H3]-trimethyl-L-lysine(9) demethylase 4D; FLJ10251; JHDM3D; JmjC domain-containing histone demethylation protein 3D; JMJD2D; jumonji domain containing 2D; Jumonji domain-containing protein 2D; KDM4D; lysine (K)-specific demethylase 4D; lysine demethylase 4D; Lysine-specific demethylase 4D; MGC141909
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Gene Symbols: KDM4D
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Molecular weight:
58,603 Da
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Basal Isoelectric point:
9.28
Predict pI for various phosphorylation states
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CST Pathways:
Histone Methylation
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