Mena Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. ENAH induces the formation of F-actin rich outgrowths in fibroblasts. Acts synergistically with BAIAP2-alpha and downstream of NTN1 to promote filipodia formation. Belongs to the Ena/VASP family. Expressed in myoepithelia of parotid, breast, bronchial glands and sweat glands. Expressed in colon-rectum muscolaris mucosae epithelium, pancreas acinar ductal epithelium, endometrium epithelium, prostate fibromuscolar stroma and placenta vascular media. Overexpressed in a majority of breast cancer cell lines and primary breast tumor lesions. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 1 H5|1 84.93 cM
Cellular Component:  actin cytoskeleton; anchoring junction; cell junction; cell projection; cytoplasm; cytoskeleton; cytosol; filopodium; focal adhesion; lamellipodium; neuron projection; plasma membrane; stress fiber; synapse
Molecular Function:  actin binding; profilin binding; protein binding; SH3 domain binding; WW domain binding
Biological Process:  actin cytoskeleton organization; actin filament organization; actin polymerization or depolymerization; actin polymerization-dependent cell motility; axon guidance; cell differentiation; cellular response to leukemia inhibitory factor; multicellular organism development; nervous system development; neural tube closure
Reference #:  Q03173 (UniProtKB)
Alt. Names/Synonyms: AI464316; AW045240; enabled homolog; enabled homolog (Drosophila); Enah; ENAH actin regulator; Mena; NDPP-1; Ndpp1; NPC derived proline rich protein 1; NPC-derived proline-rich protein 1; Protein enabled homolog; WBP8
Gene Symbols: Enah
Molecular weight: 85,844 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene