FGF23 Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL. Acts directly on the parathyroid to decrease PTH secretion. Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Belongs to the heparin-binding growth factors family. Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts). Note: This description may include information from UniProtKB.
Protein type: Cytokine; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 12p13.32
Cellular Component:  endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen
Molecular Function:  growth factor activity; protein binding; type 1 fibroblast growth factor receptor binding
Biological Process:  cell differentiation; cellular phosphate ion homeostasis; cellular protein metabolic process; cellular response to interleukin-6; cellular response to leptin stimulus; cellular response to parathyroid hormone stimulus; cellular response to vitamin D; fibroblast growth factor receptor signaling pathway; MAPK cascade; negative regulation of bone mineralization; negative regulation of hormone secretion; negative regulation of osteoblast differentiation; phosphate ion homeostasis; positive regulation of ERK1 and ERK2 cascade; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; positive regulation of transcription, DNA-templated; positive regulation of vitamin D 24-hydroxylase activity; post-translational protein modification; regulation of phosphate transport; regulation of signaling receptor activity; response to magnesium ion; response to sodium phosphate; vitamin D catabolic process
Disease: Hypophosphatemic Rickets, Autosomal Dominant; Tumoral Calcinosis, Hyperphosphatemic, Familial, 2
Reference #:  Q9GZV9 (UniProtKB)
Alt. Names/Synonyms: ADHR; FGF-23; FGF23; FGFN; Fibroblast growth factor 23; Fibroblast growth factor 23 C-terminal peptide; Fibroblast growth factor 23 N-terminal peptide; HFTC2; HPDR2; HYPF; Phosphatonin; PHPTC; tumor-derived hypophosphatemia inducing factor; Tumor-derived hypophosphatemia-inducing factor
Gene Symbols: FGF23
Molecular weight: 27,954 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB