ATP1A1 This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 1p13.1
Cellular Component:  apical plasma membrane; basolateral plasma membrane; caveola; endoplasmic reticulum; endosome; Golgi apparatus; integral component of membrane; intercalated disc; melanosome; membrane; plasma membrane; postsynaptic density; protein-containing complex; sarcolemma; sodium:potassium-exchanging ATPase complex; T-tubule
Molecular Function:  ADP binding; ankyrin binding; ATP binding; chaperone binding; phosphatase activity; phosphatidylinositol 3-kinase binding; potassium ion binding; protein binding; protein domain specific binding; protein kinase binding; sodium ion binding; sodium:potassium-exchanging ATPase activity; steroid hormone binding
Biological Process:  cardiac muscle cell action potential involved in contraction; cell communication by electrical coupling involved in cardiac conduction; cellular potassium ion homeostasis; cellular response to mechanical stimulus; cellular response to steroid hormone stimulus; cellular sodium ion homeostasis; dephosphorylation; establishment or maintenance of transmembrane electrochemical gradient; ion transmembrane transport; membrane hyperpolarization; membrane repolarization; membrane repolarization during cardiac muscle cell action potential; negative regulation of glucocorticoid biosynthetic process; negative regulation of heart contraction; positive regulation of heart contraction; positive regulation of striated muscle contraction; potassium ion import across plasma membrane; regulation of blood pressure; regulation of cardiac conduction; regulation of cardiac muscle cell contraction; regulation of sodium ion transport; regulation of the force of heart contraction; relaxation of cardiac muscle; response to drug; response to glycoside; sodium ion export across plasma membrane
Disease: Charcot-marie-tooth Disease, Axonal, Type 2dd; Hypomagnesemia, Seizures, And Mental Retardation 2
Reference #:  P05023 (UniProtKB)
Alt. Names/Synonyms: AT1A1; ATP1A1; ATPase Na+/K+ transporting subunit alpha 1; ATPase, Na+/K+ transporting, alpha 1 polypeptide; CMT2DD; HOMGSMR2; MGC3285; MGC51750; Na(+)/K(+) ATPase alpha-1 subunit; Na+, K+ ATPase alpha subunit; Na+/K+ ATPase 1; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; sodium pump 1; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide; Sodium/potassium-transporting ATPase subunit alpha-1
Gene Symbols: ATP1A1
Molecular weight: 112,896 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein