Kv2.1 a voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Contributes to the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Plays also a role in the regulation of exocytosis independently of its electrical function. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB2; channel properties depend on the type of subunits that are part of the channel. Can also form functional heterotetrameric channels with other subunits that are non-conducting when expressed alone, such as KCNF1, KCNG1, KCNG3, KCNG4, KCNH1, KCNH2, KCNS1, KCNS2, KCNS3 and KCNV1, creating a functionally diverse range of channel complexes. Major contributor to the slowly inactivating delayed-rectifier voltage-gated potassium current in neurons of the central nervous system, sympathetic ganglion neurons, neuroendocrine cells, pancreatic beta cells, cardiomyocytes and smooth muscle cells. Plays a role in the induction of long-term potentiation (LTP) of neuron excitability in the CA3 layer of the hippocampus. Contributes to the regulation of glucose-induced action potential amplitude and duration in pancreatic beta cells, hence limiting calcium influx and insulin secretion. Contributes to the pronounced pro-apoptotic potassium current surge during neuronal apoptotic cell death in response to oxidative injury. Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily. Expressed in neocortical pyramidal cells. Expressed in pancreatic beta cells. Expressed in brain, heart, lung, liver, colon, kidney and adrenal gland. Expressed in the cortex, amygdala, cerebellum, pons, thalamus, hypothalamus, hippocampus and substantia nigra. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of rat Ortholog: 3q42
Cellular Component:  apical plasma membrane; axon; cell surface; cholinergic synapse; dendrite; dendrite membrane; lateral plasma membrane; neuronal cell body; neuronal cell body membrane; perikaryon; perinuclear region of cytoplasm; plasma membrane; postsynaptic membrane; postsynaptic specialization membrane; proximal dendrite; sarcolemma; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity; outward rectifier potassium channel activity; protein binding; protein heterodimerization activity; SNARE binding; transmembrane transporter binding; voltage-gated potassium channel activity
Biological Process:  action potential; cellular response to calcium ion; cellular response to glucose stimulus; cellular response to nutrient levels; clustering of voltage-gated potassium channels; exocytosis; glucose homeostasis; glutamate receptor signaling pathway; negative regulation of insulin secretion; positive regulation of calcium ion-dependent exocytosis; positive regulation of catecholamine secretion; positive regulation of long-term synaptic depression; positive regulation of norepinephrine secretion; positive regulation of protein targeting to membrane; potassium ion export across plasma membrane; potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; protein localization to plasma membrane; regulation of action potential; regulation of monoatomic ion transmembrane transport; regulation of motor neuron apoptotic process; response to axon injury; response to L-glutamate; vesicle docking involved in exocytosis
Reference #:  P15387 (UniProtKB)
Alt. Names/Synonyms: Delayed rectifier potassium channel 1; DRK1; DRK1PC; Kcnb1; Kcr1-1; Kv2.1; potassium channel Kv2.1; potassium voltage gated channel, Shab-related subfamily, member 1; Potassium voltage-gated channel subfamily B member 1; Shab; Voltage-gated potassium channel subunit Kv2.1
Gene Symbols: Kcnb1
Molecular weight: 95,637 Da
Basal Isoelectric point: 8.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene