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PTGER1
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues. Belongs to the G-protein coupled receptor 1 family. Abundant in kidney. Lower level expression in lung, skeletal muscle and spleen, lowest expression in testis and not detected in liver brain and heart. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 19p13.12 |
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Cellular Component:
plasma membrane
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Molecular Function:
D1 dopamine receptor binding; prostaglandin E receptor activity
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Biological Process:
adenylate cyclase-activating dopamine receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; inflammatory response; positive regulation of cytosolic calcium ion concentration; response to lipopolysaccharide
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Reference #:
P34995
(UniProtKB)
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Alt. Names/Synonyms: EP1; PE2R1; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1; prostaglandin E receptor 1 (subtype EP1), 42kD; prostaglandin E receptor 1 (subtype EP1), 42kDa; prostaglandin E receptor 1, subtype EP1; Prostaglandin E2 receptor EP1 subtype; Prostanoid EP1 receptor; PTGER1
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Gene Symbols: PTGER1
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Molecular weight:
41,801 Da
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Basal Isoelectric point:
11.72
Predict pI for various phosphorylation states
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