Tau Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Cytoskeletal
Chromosomal Location of rat Ortholog: 10q32.1
Cellular Component:  axolemma; axon; axonal growth cone; axoneme; cell body; cytoplasm; cytoplasmic ribonucleoprotein granule; cytoplasmic side of plasma membrane; cytosol; dendrite; extracellular region; glial cell projection; growth cone; main axon; membrane; membrane raft; microtubule; microtubule cytoskeleton; neurofibrillary tangle; neuron projection; neuronal cell body; nuclear periphery; nuclear speck; nucleus; plasma membrane; postsynaptic density; somatodendritic compartment; tubulin complex
Molecular Function:  apolipoprotein binding; DNA binding; enzyme binding; heat shock protein binding; Hsp90 protein binding; identical protein binding; lipoprotein particle binding; microtubule binding; microtubule lateral binding; protein binding; protein kinase binding; protein phosphatase 2A binding; protein-containing complex binding; protein-folding chaperone binding; SH3 domain binding
Biological Process:  adult walking behavior; amyloid fibril formation; axo-dendritic transport; axon extension; axonogenesis; DNA damage response; female pregnancy; intracellular distribution of mitochondria; intracellular transport; intrinsic apoptotic signaling pathway in response to oxidative stress; learning or memory; memory; microtubule cytoskeleton organization; microtubule polymerization; microtubule-based process; mitochondrion transport along microtubule; mRNA transport; negative regulation of establishment of protein localization to mitochondrion; negative regulation of gene expression; negative regulation of intracellular transport; negative regulation of kinase activity; negative regulation of mitochondrial fission; negative regulation of mitochondrial membrane potential; negative regulation of tubulin deacetylation; neuron differentiation; neuron migration; neuron projection development; positive regulation of axon extension; positive regulation of long-term synaptic depression; positive regulation of microtubule polymerization; positive regulation of neuron death; positive regulation of neuron projection development; positive regulation of protein localization; positive regulation of protein localization to synapse; positive regulation of superoxide anion generation; protein homooligomerization; protein polymerization; regulation of autophagy; regulation of calcium-mediated signaling; regulation of cellular response to heat; regulation of microtubule cytoskeleton organization; regulation of microtubule polymerization or depolymerization; regulation of microtubule-based movement; response to lead ion; response to nutrient; response to organic substance; supramolecular fiber organization; synapse assembly; synapse organization
Reference #:  P19332 (UniProtKB)
Alt. Names/Synonyms: Mapt; MGC156663; Microtubule-associated protein tau; Mtapt; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; pTau; RNPTAU; Tau; Tau microtubule-associated protein
Gene Symbols: Mapt
Molecular weight: 78,564 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Microtubule Dynamics  |  Regulation of P38 MAPKs
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene