TNF-R1 Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of rat Ortholog: 4q42
Cellular Component:  axon; cell surface; cytosol; extracellular space; Golgi membrane; integral component of membrane; membrane raft; mitochondrion; nucleus; plasma membrane; protein-containing complex; receptor complex; synapse
Molecular Function:  identical protein binding; protease binding; protein binding; protein-containing complex binding; tumor necrosis factor binding; tumor necrosis factor-activated receptor activity
Biological Process:  aortic valve development; apoptotic process; cell surface receptor signaling pathway; cellular response to estradiol stimulus; cellular response to mechanical stimulus; cytokine-mediated signaling pathway; defense response; defense response to bacterium; inflammatory response; intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of apoptotic process; negative regulation of cardiac muscle hypertrophy; negative regulation of extracellular matrix constituent secretion; negative regulation of gene expression; negative regulation of inflammatory response; negative regulation of interleukin-6 production; positive regulation of angiogenesis; positive regulation of apoptotic process involved in morphogenesis; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of inflammatory response; positive regulation of neuron apoptotic process; positive regulation of transcription by RNA polymerase II; positive regulation of tumor necrosis factor production; positive regulation of tyrosine phosphorylation of STAT protein; prostaglandin metabolic process; protein heterooligomerization; protein localization to plasma membrane; pulmonary valve development; regulation of apoptotic process; regulation of establishment of endothelial barrier; response to alkaloid; response to amino acid; response to ethanol; response to hypoxia; response to lipopolysaccharide; response to wounding; tumor necrosis factor-mediated signaling pathway
Reference #:  P22934 (UniProtKB)
Alt. Names/Synonyms: CD120a; p55; p60; TNF-R1; Tnfr-1; TNFR-I; Tnfr1; TNR1A; Tumor necrosis factor receptor 1; Tumor necrosis factor receptor superfamily member 1A; Tumor necrosis factor receptor type I
Gene Symbols: Tnfrsf1a
Molecular weight: 50,969 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  Reactome  |  BioGPS  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein