hnRNP A1 Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with SEPT6. Interacts with HCV NS5B and with the 5'-UTR and 3'-UTR of HCV RNA. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear export; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 15 F3|15 58.58 cM
Cellular Component:  cytoplasm; nucleoplasm; nucleus; ribonucleoprotein complex; spliceosomal complex
Molecular Function:  mRNA binding; nucleic acid binding; RNA binding
Biological Process:  alternative mRNA splicing, via spliceosome; mRNA processing; mRNA transport; RNA splicing
Reference #:  P49312 (UniProtKB)
Alt. Names/Synonyms: D15Ertd119e; Fli-2; Hdp; HDP-1; helix destabilizing protein; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; hnRNP A1; hnRNP core protein A1; hnrnp-A1; Hnrnpa1; Hnrpa1; MGC102127; MGC102128; MGC103392; ROA1; Single-strand-binding protein; Tis; Topoisomerase-inhibitor suppressed
Gene Symbols: Hnrnpa1
Molecular weight: 34,196 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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hnRNP A1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene