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hnRNP A1
Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May bind to specific miRNA hairpins. (Microbial infection) May play a role in HCV RNA replication. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Nuclear export; RNA splicing; RNA-binding; Spliceosome |
| Chromosomal Location of mouse Ortholog: 15 F3|15 58.58 cM |
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Cellular Component:
catalytic step 2 spliceosome; cytoplasm; intracellular non-membrane-bounded organelle; nucleoplasm; nucleoplasmic periphery of the nuclear pore complex; nucleus; ribonucleoprotein complex; spliceosomal complex; synapse
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Molecular Function:
DNA binding; DNA/DNA annealing activity; G-rich strand telomeric DNA binding; identical protein binding; miRNA binding; molecular condensate scaffold activity; mRNA 3'-UTR binding; mRNA binding; nucleic acid binding; pre-mRNA binding; protein domain specific binding; RNA binding; RNA strand annealing activity; sequence-specific mRNA binding; single-stranded DNA binding; single-stranded RNA binding; telomeric repeat-containing RNA binding
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Biological Process:
alternative mRNA splicing, via spliceosome; cellular response to organic substance; cellular response to potassium ion; mRNA processing; mRNA splicing, via spliceosome; mRNA transport; positive regulation of action potential; positive regulation of gene expression; RNA splicing
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Reference #:
P49312
(UniProtKB)
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Alt. Names/Synonyms: D15Ertd119; D15Ertd119e; Fli-2; Hdp; HDP-1; helix destabilizing protein; Helix-destabilizing protein; Heterogeneous nuclear ribonucleoprotein A1; Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed; hnRNP A1; hnRNP core protein A1; hnrnp-A1; Hnrnpa1; Hnrpa1; MGC102127; MGC102128; MGC103392; ROA1; Single-strand-binding protein; Tis; Topoisomerase-inhibitor suppressed
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Gene Symbols: Hnrnpa1
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Molecular weight:
34,196 Da
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Basal Isoelectric point:
9.27
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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