TNNT2 Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin T family. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 13q13
Cellular Component:  cardiac myofibril; cardiac Troponin complex; cytoplasm; myofibril; sarcomere; striated muscle thin filament; troponin complex
Molecular Function:  actin binding; calcium ion binding; protein binding, bridging; structural constituent of cytoskeleton; tropomyosin binding; troponin C binding; troponin I binding
Biological Process:  actin crosslink formation; atrial cardiac muscle tissue morphogenesis; cardiac muscle contraction; heart development; muscle contraction; muscle filament sliding; negative regulation of ATPase activity; positive regulation of ATPase activity; protein heterooligomerization; regulation of heart contraction; regulation of muscle contraction; regulation of muscle filament sliding speed; response to bacterium; response to calcium ion; sarcomere organization; skeletal muscle contraction; ventricular cardiac muscle tissue morphogenesis
Reference #:  P50753 (UniProtKB)
Alt. Names/Synonyms: Cardiac muscle troponin T; cardiac troponin T2; cTnT; Ctt; CTTG; RATCTTG; Tnnt2; Tnnt3; TnTc; Troponin T cardiac; troponin T type 2 (cardiac); Troponin T, cardiac muscle; troponin T2, cardiac
Gene Symbols: Tnnt2
Molecular weight: 35,730 Da
Basal Isoelectric point: 4.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TNNT2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene