TNNT2
Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Belongs to the troponin T family. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. 12 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Motility/polarity/chemotaxis; Motor |
Chromosomal Location of rat Ortholog: 13q13 |
Cellular Component:
cardiac myofibril; cardiac Troponin complex; myofibril; sarcomere; sarcoplasm; striated muscle thin filament; troponin complex
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Molecular Function:
actin binding; identical protein binding; microfilament motor activity; protein-containing complex binding; protein-macromolecule adaptor activity; structural constituent of cytoskeleton; tropomyosin binding; troponin C binding; troponin I binding
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Biological Process:
actin crosslink formation; atrial cardiac muscle tissue morphogenesis; cardiac muscle contraction; heart development; muscle contraction; muscle filament sliding; negative regulation of ATP-dependent activity; positive regulation of ATP-dependent activity; regulation of heart contraction; regulation of muscle contraction; regulation of muscle filament sliding speed; response to bacterium; response to calcium ion; sarcomere organization; ventricular cardiac muscle tissue morphogenesis
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Reference #:
P50753
(UniProtKB)
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Alt. Names/Synonyms: Cardiac muscle troponin T; cardiac troponin T2; cTnT; Ctt; CTTG; RATCTTG; Tnnt2; Tnnt3; TnTc; Troponin T cardiac; troponin T type 2 (cardiac); Troponin T, cardiac muscle; troponin T2, cardiac
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Gene Symbols: Tnnt2
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Molecular weight:
35,730 Da
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Basal Isoelectric point:
4.95
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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