PHF12 Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 10q24-q25
Cellular Component:  nucleoplasm; nucleus; Sin3 complex; Sin3-type complex; transcriptional repressor complex
Molecular Function:  metal ion binding; phosphatidylinositol binding; transcription corepressor activity; transcription corepressor binding
Biological Process:  negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated
Reference #:  F1LM99 (UniProtKB)
Alt. Names/Synonyms: PHD finger protein 12; Phf12; RGD1305731
Gene Symbols: Phf12
Molecular weight: 109,602 Da
Basal Isoelectric point: 7.94  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein