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DVL2
Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Belongs to the DSH family. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis |
| Chromosomal Location of rat Ortholog: 10q24 |
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Cellular Component:
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Reference #:
D3ZB71
(UniProtKB)
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Alt. Names/Synonyms: dishevelled 2; Dishevelled segment polarity protein 2; Dvl2
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Gene Symbols: Dvl2
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Molecular weight:
78,846 Da
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Basal Isoelectric point:
5.63
Predict pI for various phosphorylation states
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CST Pathways:
Hippo Signaling
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Microtubule Dynamics
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mTOR Signaling
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Translation: eIF4E and p70S6K
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Wnt/ß-Catenin Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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