PGC-1 beta Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcritional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be part of the pathways regulating the elevation of gluconeogenesis, beta-oxidation of fatty acids and ketogenesis during fasting. Stimulates SREBP-mediated lipogenic gene expression in the liver. Induces energy expenditure and antagonizes obesity when overexpressed. Induces also the expression of mitochondrial genes involved in oxidative metabolism.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 18q12.1
Cellular Component:  mediator complex; mitochondrion; nucleus
Molecular Function:  AF-2 domain binding; estrogen receptor binding; nuclear receptor transcription coactivator activity; RNA binding; transcription coregulator activity; transcription factor binding
Biological Process:  actin filament organization; bone trabecula formation; cellular response to reactive oxygen species; intracellular estrogen receptor signaling pathway; mitochondrial transcription; negative regulation of transcription, DNA-templated; ossification; positive regulation of alkaline phosphatase activity; positive regulation of bone resorption; positive regulation of cold-induced thermogenesis; positive regulation of DNA-binding transcription factor activity; positive regulation of osteoclast differentiation; positive regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; response to cAMP; response to glucocorticoid
Reference #:  Q811R2 (UniProtKB)
Alt. Names/Synonyms: Perc; peroxisome proliferative activated receptor, gamma, coactivator 1 beta; Peroxisome proliferator-activated receptor gamma coactivator 1-beta; peroxisome proliferator-activated receptor gamma coactivator 1beta-2a; peroxisome proliferator-activated receptor gamma, coactivator 1 beta; PGC-1 beta; PGC-1-beta; Pgc1; Pgc1b; PGC1beta; PPAR-gamma coactivator 1-beta; PPARGC-1-beta; Ppargc1; Ppargc1b
Gene Symbols: Ppargc1b
Molecular weight: 111,589 Da
Basal Isoelectric point: 5.01  Predict pI for various phosphorylation states
Select Structure to View Below

PGC-1 beta

Protein Structure Not Found.


Cross-references to other databases:  Reactome  |  BioGPS  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA