CARD16 Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. Widely expressed. Expressed at higher level in placenta, spleen, lymph node and bone marrow. Weakly or not expressed in thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 11q22.3
Cellular Component:  protease inhibitor complex; protein-containing complex
Molecular Function:  CARD domain binding; caspase binding; cysteine-type endopeptidase activity; cysteine-type endopeptidase inhibitor activity; identical protein binding; kinase binding; protein binding
Biological Process:  cellular response to hypoxia; cellular response to lipopolysaccharide; cellular response to UV-C; inhibition of cysteine-type endopeptidase activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of interleukin-1 beta secretion; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of protein binding; negative regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; proteolysis
Reference #:  Q5EG05 (UniProtKB)
Alt. Names/Synonyms: CAR16; CARD only domain-containing protein 1; CARD only protein; CARD-only protein 1; CARD16; caspase recruitment domain family member 16; Caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; caspase-1 dominant-negative inhibitor pseudo-ICE; Caspase-1 inhibitor COP; COP; COP1; Pseudo interleukin-1 beta converting enzyme; pseudo interleukin-1beta converting enzyme; Pseudo-ICE; Pseudo-IL1B-converting enzyme
Gene Symbols: CARD16
Molecular weight: 22,625 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein